A cloned linguistic decision tree controller for real-time path planning in hostile environments

AbstractThe idea of a Cloned Controller to approximate optimised control algorithms in a real-time environment is introduced. A Cloned Controller is demonstrated using Linguistic Decision Trees (LDTs) to clone a Model Predictive Controller (MPC) based on Mixed Integer Linear Programming (MILP) for Unmanned Aerial Vehicle (UAV) path planning through a hostile environment. Modifications to the LDT algorithm are proposed to account for attributes with circular domains, such as bearings, and discontinuous output functions. The cloned controller is shown to produce near optimal paths whilst significantly reducing the decision period. Further investigation shows that the cloned controller generalises to the multi-obstacle case although this can lead to situations far outside of the training dataset and consequently result in decisions with a high level of uncertainty. A modification to the algorithm to improve the performance in regions of high uncertainty is proposed and shown to further enhance generalisation. The resulting controller combines the high performance of MPC–MILP with the rapid response of an LDT while providing a degree of transparency/interpretability of the decision making

Perspectives on Enabling Education for Indigenous Students at Three Comprehensive Universities in Regional Australia

Daniels, CR ORCiD: 0000-0002-0672-0450Indigenous students, particularly those from regional and remote areas, are under-represented in both higher education and vocational education in Australia. Enabling programs seek to address this under-representation. They offer pathways to higher education, are important in lifting participation rates and potentially encourage mobility between the sectors. However, strategic development of enabling programs is based on little evidence about student or staff experiences. This chapter presents a qualitative research project underpinned by the strengths-based approach of conscientisation, exploring how Indigenous learning journeys via enabling programs can respect and grow cultural identity, while simultaneously developing study skills. The research considered interpretations of ‘success’ from the perspectives of students and teachers participating in enabling courses. The research found that enabling programs were an ‘important’ and ‘exciting journey’ for students that brought about transformation of the inner self through the building of ‘resilience’, ‘strength’, ‘confidence’, ‘self-esteem’, ‘self-worth’, ‘cultural understanding’ and ‘identity’. Success was experienced across multiple dimensions of students’ lived experience including ‘cultural identity’, ‘voice’, self-realisation, self-acceptance and ‘pride’. Staff suggested that enabling programs imparted an ‘underlying layer’ of skills. Recognition of Indigenous people as ‘yarners’ and ‘story tellers’, along with ways of incorporating ‘both-ways’ methodologies, need to be considered when developing the curriculum. This chapter reports on research which will be used to inform the development of a best-practice framework for Indigenous education enabling programs in Australia, particularly in regional and comprehensive education settings

The breakthrough listen search for intelligent life: 1.1–1.9 GHz observations of 692 nearby stars

We report on a search for engineered signals from a sample of 692 nearby stars using the Robert C. Byrd Green Bank Telescope, undertaken as part of the Breakthrough Listen Initiative search for extraterrestrial intelligence. Observations were made over 1.1−1.9 GHz (L band), with three sets of five-minute observations of the 692 primary targets, interspersed with five-minute observations of secondary targets. By comparing the “ON” and “OFF” observations we are able to identify terrestrial interference and place limits on the presence of engineered signals from putative extraterrestrial civilizations inhabiting the environs of the target stars. During the analysis, eleven events passed our thresholding algorithm, but a detailed analysis of their properties indicates they are consistent with known examples of anthropogenic radio frequency interference. We conclude that, at the time of our observations, none of the observed systems host high-duty-cycle radio transmitters emitting between 1.1 and 1.9 GHz with an Equivalent Isotropic Radiated Power of ∼ 1013 W, which is readily achievable by our own civilization. Our results suggest that fewer than ∼ 0.1% of the stellar systems within 50 pc possess the type of transmitters searched in this survey

Dose-Dependent Effects of Endotoxin on Neurobehavioral Functions in Humans

Clinical and experimental evidence document that inflammation and increased peripheral cytokine levels are associated with depression-like symptoms and neuropsychological disturbances in humans. However, it remains unclear whether and to what extent cognitive functions like memory and attention are affected by and related to the dose of the inflammatory stimulus. Thus, in a cross-over, double-blind, experimental approach, healthy male volunteers were administered with either placebo or bacterial lipopolysaccharide (LPS) at doses of 0.4 (n = 18) or 0.8 ng/kg of body weight (n = 16). Pro- and anti-inflammatory cytokines, norephinephrine and cortisol concentrations were analyzed before and 1, 1.75, 3, 4, 6, and 24 h after injection. In addition, changes in mood and anxiety levels were determined together with working memory (n-back task) and long term memory performance (recall of emotional and neutral pictures of the International Affective Picture System). Endotoxin administration caused a profound transient physiological response with dose-related elevations in body temperature and heart rate, increases in plasma interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α and IL-1 receptor antagonist (IL-1ra), salivary and plasma cortisol, and plasma norepinephrine. These changes were accompanied by dose-related decreased mood and increased anxiety levels. LPS administration did not affect accuracy in working memory performance but improved reaction time in the high-dose LPS condition compared to the control conditon. In contrast, long-term memory performance was impaired selectively for emotional stimuli after administration of the lower but not of the higher dose of LPS. These data suggest the existence of at least two counter-acting mechanisms, one promoting and one inhibiting cognitive performance during acute systemic inflammation

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Background The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea. Methods We used data from two prospective cohort studies: PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up. Findings We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01–1.03), male (1.54, 1.16–2.04), neither obese nor severely obese (1.82, 1.06–3.13 and 4.19, 2.14–8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09–2.22) or cardiovascular disease (1.33, 1.00–1.79), and shorter hospital admission (1.01 per day, 1.00–1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission). Interpretation Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19. Funding PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care. COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders

COVID-19: Rapid antigen detection for SARS-CoV-2 by lateral flow assay: A national systematic evaluation of sensitivity and specificity for mass-testing

Background Lateral flow device (LFD) viral antigen immunoassays have been developed around the world as diagnostic tests for SARS-CoV-2 infection. They have been proposed to deliver an infrastructure-light, cost-economical solution giving results within half an hour. Methods LFDs were initially reviewed by a Department of Health and Social Care team, part of the UK government, from which 64 were selected for further evaluation from 1st August to 15th December 2020. Standardised laboratory evaluations, and for those that met the published criteria, field testing in the Falcon-C19 research study and UK pilots were performed (UK COVID-19 testing centres, hospital, schools, armed forces). Findings 4/64 LFDs so far have desirable performance characteristics (orient Gene, Deepblue, Abbott and Innova SARS-CoV-2 Antigen Rapid Qualitative Test). All these LFDs have a viral antigen detection of >90% at 100,000 RNA copies/ml. 8951 Innova LFD tests were performed with a kit failure rate of 5.6% (502/8951, 95% CI: 5.1–6.1), false positive rate of 0.32% (22/6954, 95% CI: 0.20–0.48). Viral antigen detection/sensitivity across the sampling cohort when performed by laboratory scientists was 78.8% (156/198, 95% CI 72.4–84.3). Interpretation Our results suggest LFDs have promising performance characteristics for mass population testing and can be used to identify infectious positive individuals. The Innova LFD shows good viral antigen detection/sensitivity with excellent specificity, although kit failure rates and the impact of training are potential issues. These results support the expanded evaluation of LFDs, and assessment of greater access to testing on COVID-19 transmission. Funding Department of Health and Social Care. University of Oxford. Public Health England Porton Down, Manchester University NHS Foundation Trust, National Institute of Health Research